Which of the following is a skin effect associated with high-dose radiation therapy?

Desquamation is a well-recognized skin effect that can occur as a result of high-dose radiation therapy. This term refers to the shedding or peeling of the outer layers of the skin, which is typically a response to damage caused by the radiation. In high-dose treatments, the skin cells are significantly affected, leading to the breakdown of the epidermis. This process can result in various degrees of skin peeling, which may vary from mild flaking to severe moisture loss and ulceration, depending on the radiation dosage and individual patient sensitivity.

The other choices represent skin effects that can occur but are not as directly associated or severe as desquamation in the context of high-dose radiation therapy. Hypopigmentation may occur due to changes in melanocyte function, acne is often related to other conditions rather than radiation effects, and dryness can result from various causes, including radiation but is more generalized and not exclusive to high doses. Therefore, desquamation stands out as the primary and significant skin effect specifically linked to high-dose radiation exposure.